Collagen Injections

Collagen Injections

Collagen injections

Biogel on the basis of human and bovine collagen

Plastic Surgery – – 2009

Collagen can be applied to persons aged 35-60 years, to eliminate the wrinkles, "crow's feet" around the eyes and mouth, as well as smoothing nasolabial folds. Collagen should not apply to pregnant women and breastfeeding women, as well as those who are allergic to bovine collagen and lidocaine, as well as patients with certain autoimmune diseases.

Collagen – a protein which is composed of fibers that are an integral part of the connective tissue, along with elastin fibers and hyaluronic acid. Collagen is used in cosmetology to eliminate wrinkles on the face, Lions, smooth skin of the nasolabial folds, corners of the eyes and mouth. Previously, the collagen was a very popular filler, but with the development of other, newer materials biogels, its use has decreased.

For the purpose of cosmetic surgery are two types of collagen: the human and bovine.

The action of injectable collagen

As already mentioned, collagen – is the main type of fiber present in connective tissue. A connective tissue in humans is, of course, not only in the skin, but also in other tissues – in the cartilage, bone and blood vessels. Collagen makes up 80% of the skin. It provides the strength of the collagen of the skin and its elasticity. However, collagen – will not last forever. With age it becomes less stable and less elastic. New collagen fibers are formed fewer and smaller, and the skin wrinkles. Collagen injections can quickly make this a deficiency in the skin and remove wrinkles and creases.

On the market there are several types of collagen, which may be based on the human (KosmoDerm, KosmoPlast) or bovine (Zyderm, Zyplast) collagen. In addition, there is a combined gel – Artefill, which contains methyl methacrylate in microspherical form, suspended in bovine collagen with added anesthetic lidocaine.
Bovine collagen

Of what are bovine collagen?

Bovine collagen – a highly purified collagen obtained from bovine skin tissue.

Bovine collagen and Allergy

Since collagen is a foreign protein, it can cause allergic reactions such as redness, itching and swelling. That is why before applying gels on the basis of bovine collagen allergy test done necessarily. This is done by introducing into the skin of the forearm a small dose of collagen, followed by the introduction of a place for observation, usually within 4 weeks. If the patient has an allergy to bovine collagen, in the place of its introduction marked symptoms such as redness, itching and swelling.

The method of introducing the collagen

Before using these gels as Zirderm and Zyplast, is held allergy reaction. Typically, collagen injections are carried out in the doctor's office, that is an outpatient (which means that specially go to the clinic is not necessary). All of collagen injections are carried out without anesthesia, because of the gels is already included anesthetic, usually lidocaine. However, in the first 1-2 seconds, the introduction of the gel can still feel the pain. Collagen is injected with a syringe and fine needle into the space of folds and wrinkles. Depending on the number and depth of wrinkles on the skin, may require several such injections. Usually the whole procedure can take up to one hour.

Before you enter the collagen, a doctor usually marks on the skin of a place where to enter the gel, and decides what amount of gel needed. The very saline gel contains sodium chloride, in which collagen is dissolved. So the first time after injection of the skin may look slightly swollen. After a short time, the swelling goes away.

The duration of the effect of bovine collagen is approximately 4 – 6 months. Then, the collagen is gradually absorbed and the need for new injections. In 97% of Zyderm and Zyplast can be used in people who were allergy test for this filler.

Side effects of drugs of bovine collagen: redness, swelling, pain, itching, discoloration and skin sensitivity.

The human collagen

There are several bio-gel-based human collagen: Saymetra, KosmoDerm, KosmoPlast, Dermologen, Autologen, Izologen.


Saymetra – this gel is synthesized from the treated skin of the corpse, devoid of cells. The composition of the filler includes all the components of the skin, which are needed for the upgrade – collagen and elastin, proteins and proteinglikany. Collagen and elastin – fibers are the main skin, which is its frame. These fibers 'grows' skin cells. Well protiny proteinglikany and provide the appearance of new components of the skin.
Saymetra used for: lip augmentation, correction of nasolabial folds, deep and eliminate wrinkles, smooth out acne scars, as well as for laryngeal injections (in the vocal cords).

Since saymetra Filler is based on human tissue, it does not cause any allergic reactions or inflammation. Also, another plus Saymetry is that there is no need to take tissue from your body. The effect of this filler lasts longer than after the application of a simple collagen.

KosmoDerm and KosmoPlast

It is also one of the types of human collagen. As Saymetra, it has no allergic properties, so there is no need for a sample before its introduction. The composition of the filler also includes lidocaine, which provides a comfortable introduction of the gel. Duration of effect and KosmoDerma KosmoPlasta about 6 months.

KosmoDerm and KosmoPlast apply to: eliminate wrinkles on the forehead, the correction of nasolabial folds and wrinkles of the skin in the alignment of the nose, smoothing of wrinkles around the mouth and around the eyes, lips increased.


This type of filler on the basis of human collagen, which is derived from a special bank of the skin. This collagen is a specially processed to be transformed into a gel form. Over time, Dermologen resolves, but the duration of its effects last longer than conventional types of collagen.

Application Dermologena shown for: the correction of nasolabial folds and wrinkles of the skin in the alignment of the nose, smoothing of wrinkles around the mouth and around the eyes, removal of scars, dimples, after acne.


Autologen – is collagen, which is derived from a patient's own skin. Once the patient has taken the skin, it is sent to a special laboratory where it is processed to extract collagen from it. Further, this collagen is stored in a frozen form, and can be used as needed.

Note that this collagen is more expensive than other types of collagen, but the huge advantage is that it is not rejected by the body as it is – your own body tissue. Test for allergy to conduct this collagen is not necessary. Duration of effect Autologena up to 9 months.


Izolgen represents fibroblasts isolated skin of the patient's own. These fibroblasts are specially grown in the laboratory. This filler stimulates the synthesis of collagen fibers in the skin. The duration of the effect of such a filler is unbounded, although they are subject to aging collagen fibers with age.

Izolagen can be used to: correction of nasolabial folds, removing wrinkles in the nose, smoothing the wrinkles in the lips, lip augmentation, removal of scars after acne.

The recovery period

After the introduction of collagen, there may be some discomfort. This can be expressed in the form of swelling of the skin at the injection site, formation of a small bruise. Typically, these phenomena are in 48 hours. On the first day can be marked as redness, which can last up to a week.

Immediately after the injection procedure, you can go home. The results after the introduction of collagen – the immediate, that is, you do not have to wait until the injection will work. However, after some time entered the collagen dissolves (depending on the type of filler injected). Therefore, to maintain the results, you will need to periodically re coming to the injection.

Complications after the injection of collagen

Usually, complications after collagen injections is minimal. Among the possible complications can be noted uneven texture of the skin, allergic reactions (to the bovine collagen, lidocaine), and the entry of infection and scarring.

An alternative to collagen

In order to eliminate lines and wrinkles Botox can also be used, which can be used in combination with collagen or Restylane, Rediens, Hialaform or laser resurfacing. In the deeper folds of the skin can be used surgical methods of correction, such as facelifts, eyebrow lifting and forehead, and blepharoplasty.

PLASTIC SURGERY in Germany – Plastic Surgery Clinic OPTIMA
Department of Plastic Surgery CB 6 RZD – MOSCOW

Examination and treatment in GERMANY – Institute "DIAGNOSTIX"