Archive for the ‘Andrology’ Category

BPA increases risk of cancer in human prostate tissue, study shows

Bisphenol A, or BPA, is widely used to soften plastics. Steering clear of the chemical is nearly impossible, says Gail Prins, professor of physiology at UIC and lead author of the paper.

"Previous studies have shown that people who avoided all contact with plastics or other BPA-containing objects for up to a month or more still had BPA in their urine, which means they must have come into contact with BPA in the last 24 to 48 hours, since it clears the body rather quickly," said Prins, who is director of the UIC andrology laboratory. "It’s very hard to avoid."

Exposure of the fetus to BPA in utero is of particular concern, because the chemical, which mimics the hormone estrogen, has been linked to several kinds of cancer, including prostate cancer, in rodent models. The new findings show that human prostate tissue is also susceptible.

"Our research provides the first direct evidence that exposure to BPA during development, at the levels we see in our day-to-day lives, increases the risk for prostate cancer in human prostate tissue," Prins said. "The findings of adverse effects of BPA in human tissue are highly relevant and should encourage agencies like the Food & Drug Administration to re-evaluate their policies in the near future."

Prins investigated the effect of BPA on human cells by implanting human prostate stem cells taken from deceased young-adult men into mice. Prostate stem cells are very long-lived. They arise during early fetal development and produce and maintain a man’s prostate tissue throughout his life.

To mimic exposure to BPA during embryonic development, for two weeks following implantation the mice were fed BPA — in amounts in line with those seen in pregnant American women — as the cells produced humanized prostate tissue.

"The amount of BPA we fed the mice was equivalent to levels ingested by the average person," Prins said. "We didn’t feed them exorbitantly high doses."

After the tissue was allowed to mature for one month, the mice were given estrogen to mimic the naturally rising estrogen levels seen in aging men. This rise in estrogen later in life is one of the known drivers of prostate cancer.

Tissue was collected after two to four months and analyzed for prostate disease. Prins found that a third of tissue samples taken from mice fed BPA had either pre-cancerous lesions or prostate cancer, compared to only 12 percent in a control group of mice fed oil. If the prostate stem cells were exposed to BPA before implantation and again as they produced prostate tissue in the mice, 45 percent of the tissue samples had pre-cancerous lesions or cancer.

"We believe that BPA actually reprograms the stem cells to be more sensitive to estrogen throughout life, leading to a life-long increased susceptibility to diseases including cancer," Prins said.

source : http://www.sciencedaily.com/releases/2014/01/140107135759.htm

Phimosis

Phimosis

Phimosis

What is phimosis?

Andrology – EURODOCTOR.RU – 2007

Department of Plastic and Reconstructive Surgery CB 6 RZD – MOSCOW
Phimosis – a narrowing of the opening of the foreskin that prevents exposure of the glans penis. Phimosis – a fairly common disease. Traditionally called phimosis and congenital narrowness of the prepuce. That is not a disease and there is a majority of newborn boys. It is noted that only 4% of newborn boys have the opportunity to fully expose the glans penis. In 90% of them the head is fully exposed to only three years. At the age of 17 violations of exposure heads noted in only 1% of adolescents. Phimosis in adults may develop secondary to poor personal hygiene, as well as some associated diseases (eg diabetes).
Need to dwell on the two anomalies. The foreskin of boys, some long, dangling like a trunk (hypertrophic), and others – short, with thinned margins and a narrow aperture (atrophied). The free mobility of the foreskin in the first case occurs somewhat later, and with a short foreskin can only be a partial release of the glans penis – prevents the narrow opening.
There are times when the inner layer of the foreskin and the glans penis spliced across the surface, but more frequently in the coronary sulcus. Sometimes the opening of the foreskin is so narrow that one has to resort to the instrument of its expansion, sometimes it becomes necessary surgery, there is a disease – a true phimosis.

Andrology and Urology Clinic of Professor GEPELYA – GERMANY
Andrology and urology at the Medical Center Imedical – ISRAEL
Clinic Andrology and genital surgery in MOSCOW

Examination and treatment in GERMANY – Institute "DIAGNOSTIX"

AID IN THE TREATMENT –
Children phimosis – phimosis in a child
The problem of phimosis in adults
Circumcision – Circumcision

Paraphimosis

Paraphimosis

Paraphimosis

Treatment for paraphimosis

Andrology – EURODOCTOR.RU – 2007

Department of Plastic and Reconstructive Surgery CB 6 RZD – MOSCOW
Paraphimosis – as a complication of congenital and acquired phimosis. If the foreskin, with an effort to attenuate coronary sulcus of the penis has not been returned back, then it infringes on his head, causing her swelling. In the head there is a partial impairment of blood circulation, leading to its necrosis.
This gives rise to pain in the glans penis prejudice, cyanosis and edema.
To avoid development of irreversible changes in the head of the penis (such as necrosis), apply the following method. At the head of the penis jam thumbs with gauze soaked in liquid paraffin (or glycerol), the other ring finger pulled the foreskin forward. If you head this way was right, the patient usually appointed baths with a slightly pink solution of potassium permanganate until the complete elimination of edema. Otherwise, the cut is squeezing the ring of the foreskin, which helps to release the head. In practice, this is the same as the dissection of phimosis. It is best to make a circular excision.

Andrology and Urology Clinic of Professor GEPELYA – GERMANY
Andrology and urology at the Medical Center Imedical – ISRAEL
Clinic Andrology and genital surgery in MOSCOW

Examination and treatment in GERMANY – Institute "DIAGNOSTIX"

AID IN THE TREATMENT –

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