Syndrome of Morgagni-Stewart-Morel (frontal hyperostosis)
Hyperostosis – Elite Treatment in Europe
Syndrome of Morgagni-Stewart-Morel – a disease in which there are obesity, a thickening of the inner plate of the frontal bone and virilization.
Virilization (from the Latin virilis – male) – the appearance of male characteristics in women under the influence of male sex hormone androgen.
The reason for the frontal hyperostosis is unknown. Presumably, the trigger of the disease are changes in the hypothalamic-pituitary system, which occur during the female menopause.
Microscopic examination of the pituitary gland in this disease show a lot of microadenomas (benign tumor of glandular tissue formation), the pituitary gland. In microadenomas is enhanced production of somatotropic and adrenocorticotropic pituitary hormones.
Excess of somatostatin causes a thickening of the internal plates of the skull bones, increasing the size of the sella turcica (bone box in which the pituitary gland), bony growths of the skull bones and spine. Increased production of adrenocorticotropic hormone causes an increased synthesis of adrenal hormones. This is usually manifested Cushing's syndrome, lung (redundant function of the adrenal cortex).
Clinical manifestations of hyperostosis.
There obesity, high blood pressure, impaired glucose uptake tissues of the human body. Sick women during menopause and beyond. The disease begins slowly. First, there are persistent headaches in the forehead or the nape of the neck, often compressing character constants not depending on the position of the head. Due to persistent headache there is irritability, nervousness, and various sleep disorders.
Gradually developing a uniform whole-body obesity. The bands stretch and there is no, but may appear excessive hair growth on face and body.
Patients worried about shortness of breath, palpitations, high blood pressure. Often under the influence of adrenal hormones is a violation of carbohydrate metabolism and diabetes, there is the second type. The menstrual cycle is disturbed, but the tides, as during menopause, does not happen.
In the future, compounded by disorders of the central nervous system, until the development of depression.
Diagnosis of hyperostosis.
The diagnosis is established on the basis of:
- age of patients
- characteristic of obesity
- excessive growth of body hair.
Pre-ray study found a thickening of the inner plate of the frontal bone, bone growths on the skull.
In the blood, a higher amount of:
- hormones of the adrenal cortex.
Treatment of the syndrome of Morgagni-Stewart-Morel.
Most drug treatment. First of all, is assigned a diet with fewer calories fat and carbohydrate-rich foods. Sometimes medications are used to reduce appetite. Be sure to need sufficient exercise. If you have diabetes are appointed agents for its treatment. With persistent increase in blood pressure are appointed agents for the treatment of hypertension. In some patients there is a need radiation therapy.
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