Lobular carcinoma in situ of the breast
The defeat of the lobules of the breast
Mammology – Breast surgery – Eurodoctor.ru – 2008
Lobular carcinoma is considered to be primarily precancerous condition. The term "lobular" means that a defeat for the lobules of the breast.
Usually, when this disease the abnormal cells are widely distributed throughout the mammary gland and often found in both glands simultaneously. This form of carcinoma is much rarer than, for example, ductal carcinoma. However, and lobular carcinoma may mean that women have an increased risk of developing breast cancer in the future.
The results of many long-term studies suggest that 25% of women with lobular (ie lobular) carcinoma in situ, for 25 years after the diagnosis of lobular carcinoma detection appears invasive breast cancer. Therefore, in this case, as in ductal carcinoma is very important early diagnosis is necessary to identify patients at high risk for the possible development of invasive breast cancer.
In a prospective study conducted by the National Surgical Adjuvant Breast Project, and intestinal tumors (National Surgical Adjuvant Breast and Bowel Project) 182 women with a 5-year survival, suffering from lobular carcinoma in situ, only the last biopsy, only 8 of them had developed a tumor in the affected breast (4 tumors were invasive at the same time), and three women developed cancer in the contralateral breast.
The basic principles of treatment of lobular carcinoma in situ today include surgery or the use of hormone replacement therapy antiestrogen in order to reduce the risk of developing invasive cancer. A common form of control over the course of the disease in women with lobular carcinoma in situ – this observation. The majority of patients usually do not make any additional treatment after surgical removal of carcinomas for diagnostic analysis – excisional biopsy. Patients who choose the path of observation, must undergo an annual inspection and if necessary – the subsequent biopsy.
In addition, despite the fact that mammography is insensitive to a large extent in the recognition of invasive lobular breast cancer, this study of women must be conducted annually.
Furthermore, in addition to mammography for women with lobular carcinoma in situ is required to periodically undergo computed tomography or magnetic resonance imaging (MRI).
Breast Center Dr. FALBREDE – GERMANY
CANCER CENTER "LSOD"
Mammology in MOSCOW – Medical Center Health Institute
Examination and treatment in GERMANY – Institute "DIAGNOSTIX"
AID IN THE TREATMENT –
Invasive lobular carcinoma of the breast
Lobular carcinoma and increased risk of cancer